Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection

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Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection

Salmonella Typhimurium sequence type (ST) 313 produces septicemia in infants in sub-Saharan Africa. Although there are known genetic and phenotypic differences between ST313 strains and gastroenteritis-associated ST19 strains, conflicting data about the in vivo virulence of ST313 strains have been reported. To resolve these differences, we tested clinical Salmonella Typhimurium ST313 and ST19 s...

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The Role of the st313-td Gene in Virulence of Salmonella Typhimurium ST313

Multidrug-resistant Salmonella enterica serovar Typhimurium ST313 has emerged in sub-Saharan Africa causing severe infections in humans. Therefore, it has been speculated that this specific sequence type, ST313, carries factors associated with increased pathogenicity. We assessed the role in virulence of a gene with a yet unknown function, st313-td, detected in ST313 through comparative genomic...

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Signatures of Adaptation in Human Invasive Salmonella Typhimurium ST313 Populations from Sub-Saharan Africa

Two lineages of Salmonella enterica serovar Typhimurium (S. Typhimurium) of multi-locus sequence type ST313 have been linked with the emergence of invasive Salmonella disease across sub-Saharan Africa. The expansion of these lineages has a temporal association with the HIV pandemic and antibiotic usage. We analysed the whole genome sequence of 129 ST313 isolates representative of the two lineag...

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Correction: Signatures of Adaptation in Human Invasive Salmonella Typhimurium ST313 Populations from Sub-Saharan Africa

There are several errors in this published article. In the penultimate sentence of part A the Fig 1 legend, the word “pseudogenes” in the parentheses should read “prgH”. The table legend for Table 3 is missing. Please see the complete, correct Table 3 legend here. Table 3. Gene accession numbers/IDs. The common gene name, uniprot ID and Embl accession for all genes described in the text are pro...

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Correction: Correction: Signatures of Adaptation in Human Invasive Salmonella Typhimurium ST313 Populations from Sub-Saharan Africa

This correction is being issued to modify a previous correction. The second sentence should be modified to the following: Figure 1. Due to a typographical error, prgH is mistakenly listed as a pseudogene. Diseases Staff. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any me...

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ژورنال

عنوان ژورنال: PLOS Neglected Tropical Diseases

سال: 2017

ISSN: 1935-2735

DOI: 10.1371/journal.pntd.0005697